The MS6.4 earthquake occurred in Yangbi,Yunnan on May 21st, 2021 with a focal depth of 8 km. In this paper, UAV remote sensing technology was introduced into the building damage assessment work of thisearthquake. Combining UAV images and field ground survey data,remote sensing interpretation signs of building earthquake damage was established,building earthquake damage information in some areas of Yangbi County was extracted, and remote sensing quantitative evaluation was carried out. Through comparative analysis with thestatistical results of the field earthquake damage investigation, the quantitative remote sensing assessment resultsof housing earthquake damage in the study area were consistent with the field survey results. The results indicatedthat interpretation of the UAV remote sensing images acquired rapidly after the earthquake combining with the fieldsampling investigation can make a macro judgment on the earthquake intensity of the disaster area, and provide effective decision supports for earthquake scene command and emergency rescue.